Tramadol vs Oxycodone: A Comparison
Tramadol and oxycodone are both opioids, but they differ in their molecular structures, which leads to variations in potency and addiction potential. One significant distinction is that oxycodone is approximately 1.5 times more powerful than morphine, while tramadol is only 10% as potent as morphine.
| Particulars | Tramadol | Oxycodone |
| Drug Schedule | Schedule IV | Schedule II |
| Dosage | Starting dosage of 50 mg every 4-6 hours as required, with a maximum daily dose of 400 mg | Start with 5 mg every 4-6 hours as needed. |
| Is sold in conjunction with other medications. | Yes, with acetaminophen | Yes, with acetaminophen, aspirin, buprofen or naloxone |
| Brand | Ultram | OxyContin, Xtampza ER, Oxaydo |
Tramadol: What Is It?
Tramadol is a prescription-only painkiller that is slightly less potent than other opioids. It affects the central nervous system by binding to opioid receptors in the body. While tramadol may not be as strong as some other opioids, it is still effective for relieving severe pain. For chronic and severe pain requiring continuous treatment, extended-release medications are available.
How Does Oxycodone Work?
Oxycodone is a potent semi-synthetic opioid that is tightly regulated due to its potential for misuse and addiction. Like tramadol, it affects the central nervous system to alter pain perception. However, unlike tramadol, oxycodone does not inhibit the reuptake of norepinephrine and serotonin.
Tramadol vs Oxycodone
Tramadol is classified as a Schedule IV substance, while oxycodone is Schedule II due to their differences in potency. Both drugs carry a risk of addiction, but oxycodone has a higher potential for misuse and addiction.
Both oxycodone and tramadol can lead to physical dependency and addiction if not used under medical supervision. Prolonged use of these drugs can result in physical dependence, where withdrawal symptoms occur when the drug is discontinued.
Is Oxycodone or Tramadol More Powerful?
Tramadol and oxycodone are both powerful painkillers, but oxycodone is stronger in reducing pain. Tramadol is typically used for less severe pain due to its lower potency. Oxycodone has a quicker onset of pain relief compared to other painkillers and carries a higher risk of misuse and addiction. Tramadol has a lower risk of addiction but an increased risk of seizures.
