The Most Common Depression Symptoms
Depression can manifest in various ways, with some individuals experiencing fatigue and sadness while others may exhibit irritability or aggression. Additional symptoms of depression include:
- Loss of interest in activities
- Changes in sleep patterns
- Changes in appetite
- Feelings of guilt or hopelessness
- Lack of energy
- Difficulty concentrating
- Thoughts of suicide
How is an overdose handled?
In the event of an overdose, emergency responders will transport the individual to the hospital or emergency department. Treatment may involve the administration of activated charcoal during transportation. Upon arrival, the doctor may pump the stomach to remove any remaining medication. If the individual is agitated or hyperactive, they may be sedated with benzodiazepines. Medication to block serotonin may also be given if symptoms of serotonin syndrome are present. Intravenous fluids may be necessary to replenish nutrients and prevent dehydration. After symptoms have subsided, observation in the hospital may be required.
What are the most common and fatal doses?
TCAs
Tricyclic antidepressants (TCAs) have a higher number of fatal overdoses compared to other antidepressants. The typical daily dose of TCA amitriptyline ranges from 40 to 100 milligrams (mg), while imipramine is typically prescribed at doses between 75 and 150 mg per day. According to a 2007 assessment of US poison center data, life-threatening symptoms often occur with quantities exceeding 1,000 mg of TCAs. In one clinical study, the lowest lethal dose of imipramine was found to be only 200 mg.
SSRIs
An overdose of selective serotonin reuptake inhibitors (SSRIs) is rarely fatal when taken alone. The average daily dosage of fluoxetine (Prozac) ranges from 20 to 80 mg. While a dose as low as 520 mg of fluoxetine has been linked to death, individuals who ingest 8 grams of fluoxetine have been known to recover. Serotonin-norepinephrine reuptake inhibitors (SNRIs) are less dangerous than TCAs but more harmful than SSRIs. Venlafaxine, an SNRI, is typically prescribed in divided doses of 75 to 225 mg per day. Most SNRI overdoses, even at higher doses, are not lethal and fatal cases often involve multiple drugs.
MAOIs
Monoamine oxidase inhibitors (MAOIs) are older antidepressants that are no longer commonly used. Instances of MAOI toxicity usually occur when excessive doses are combined with alcohol or other medications. Death from an MAOI overdose is rare, likely due to the decreased prescription of these medications because of their numerous interactions.
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