What are the top-selling pain medications in the USA according to Pharmauniversal?

What are the top-selling pain medications in the USA according to Pharmauniversal?

Are you experiencing cramps, a strained muscle, or a headache? Over-the-counter painkillers like Ibuprofen or acetaminophen can provide relief. Unlike prescription opioid-containing pain medications, OTC painkillers are not addictive and are unlikely to cause drowsiness, dizziness, or constipation. Generic alternatives to brand-name OTC painkillers are available at pharmacies, offering the same effectiveness at a lower price.

To determine the satisfaction level of people using over-the-counter pain relievers, we conducted a review of medication feedback from a sample size of approximately 4,000 individuals.

The results showed that the majority of individuals find over-the-counter pain remedies effective – at least 75% of reviewers considered each of the mentioned prescriptions worthwhile.

Chronic Pain and Acute Pain

Pain can be categorized into two types. Acute pain occurs suddenly, lasts for a short period, and disappears as the body recovers. It can be experienced as severe pain following surgery or due to conditions such as a fractured bone, infected tooth, or kidney stone.

Chronic pain can be caused by medical conditions like arthritis or as a result of intense pain following an accident, surgery, or resolved health issue, such as post-herpetic neuralgia after shingles.

Citric acid/aspirin/sodium bicarbonate

The combination of aspirin, sodium bicarbonate, and citric acid in Alka-Seltzer acts as a pain reliever and antacids.

Since it contains aspirin, this over-the-counter pain reliever carries the same warnings and precautions as regular aspirin, including its blood-thinning effects. Aspirin should not be taken by individuals under the age of 19 due to the risk of Reye’s syndrome, a condition that can cause liver and brain damage when taken in large amounts. Individuals with heart failure should avoid using this medication due to its salt concentration.


Oxycodone is a potent opioid drug used to treat moderate to severe pain. It works by attaching to opioid receptors in the brain and spinal cord, reducing pain transmission throughout the body. This can provide significant pain relief, particularly for acute and chronic pain conditions.

Oxycodone is available in immediate-release and extended-release forms. Immediate-release oxycodone acts quickly to relieve acute pain from post-operative discomfort or trauma.

Many individuals tolerate oxycodone well, meaning it can effectively relieve pain with minimal side effects.


Tramadol is a short-term treatment for moderate to severe pain. It acts directly on opioid receptors in the central nervous system, interfering with the communication of pain sensations between the brain and the body.


Jpdol 100mg Tablet is an analgesic (pain reliever) used to treat pain ranging from moderate to severe. It contains both acetaminophen and tramadol, preventing the formation of pain-causing molecules (prostaglandins).

Buy the best painkillers in the USA from Pharmauniversal!

Pharmauniversal offers a wide variety of medicines to alleviate acute and chronic pain. We provide guaranteed and safe medications delivered to your doorstep within 24 hours. Our 24×7 chat support allows you to discuss your concerns with our representatives. We prioritize the safety and security of our customers’ profiles.

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