What Is Tramadol?
Tramadol is an opioid-based prescription pain reliever. It was previously considered a less dangerous opioid pain medication for certain patients. However, it can still be misused and lead to addiction.
How long does tramadol take in the body?
The mechanism of action of tramadol explains its pharmacological properties, including its duration in the body. After ingestion, it is transformed into desmethyltramadol by liver enzymes. Tramadol mimics the actions of endorphins, the body’s natural pain control chemicals. It remains active in the body for approximately 24 to 32 hours after initial usage.
Tramadol Degradation in the Body
The path of tramadol through the human body is influenced by various factors. The drug’s availability depends on the dosage and formulation. Tramadol can be administered orally, rectally, or intravenously. Injectable methods provide full bioavailability, while oral and rectal routes offer around 75% of the medication.
Once in the bloodstream, tramadol may remain or be redistributed to different areas. Tramadol distribution is influenced by individual characteristics such as genetics and body composition. A portion of tramadol becomes protein-bound in the blood, limiting its accessibility to other bodily compartments.
The enzyme CYP3D6 converts tramadol into desmethyltramadol. The remaining tramadol is slowly eliminated from the body through urine and stools. The steady state concentration refers to the proportion of drug remaining when intake and excretion rates equalize.
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