Individuals frequently buy generic tramadol to treat neuropathic pain
Many people turn to generic tramadol when over-the-counter pain relievers fail to provide significant relief for neuropathic pain. While antidepressants are commonly used to treat this type of pain, Oxycodone has also been proven effective in reducing neuropathic pain in placebo-controlled trials.
Oxycodone, also known as Roxicodone and OxyContin (the extended-release version), is a highly potent semi-synthetic opioid used for moderate to severe pain. However, it is important to note that Oxycodone is highly addictive and often misused. It is typically taken orally and comes in immediate-release and controlled-release forms.
The immediate-release formulation provides pain relief within fifteen minutes and lasts up to six hours. In the United Kingdom, it is also available as an injection. Combination medications containing paracetamol (acetaminophen), ibuprofen, naloxone, naltrexone, and aspirin are also available.
What is the purpose of Oxycodone?
Oxycodone is prescribed to treat moderate to severe pain. It is specifically used for individuals who require around-the-clock pain medication for an extended period and have not responded well to other drugs. It belongs to the opiate (narcotic) analgesics family and works by altering the brain and nerve system’s response to pain.
Oxycodone is also available in combination with other substances such as acetaminophen, aspirin, and ibuprofen. However, this article focuses solely on the usage of oxycodone on its own.
Dosing
For oral administration (extended-release capsules):
- For extreme pain in patients not using narcotics or opioid tolerant: Initially, take 9 mg every 12 hours with meals. The daily dosage should not exceed 288 mg.
For oral administration (capsules) for moderate to severe discomfort in adults:
- Initially, take 5 to 15 mg every 4 to 6 hours as needed.
For oral administration (immediate-release tablets) for moderate to severe discomfort in adults:
- Initially, take 5 to 15 mg every 4 to 6 hours as needed. Your doctor may adjust the dosage if necessary.
For oral administration (liquid concentrate or solution) for moderate to severe discomfort in adults:
- Take 10 to 30 mg every 4 hours as required.
For oral administration (tablets) for moderate to severe discomfort in adults:
- Initially, take 5 to 15 mg every 4 to 6 hours as needed. Your doctor may adjust the dose if required and tolerable.
Overdose
Oxycodone can cause serious side effects and even death when taken in large doses or by individuals who are not opioid tolerant. Symptoms of overdose include shallow breathing, decreased heart rate, cold/clammy skin, pauses in breathing, low blood pressure, constricted pupils, circulatory collapse, and respiratory arrest.
In recent years, heroin and fentanyl have become increasingly prominent causes of drug-related fatalities in the United States. However, Oxycodone was the leading cause of drug-related fatalities in 2011.
Oxycodone overdose has also been associated with spinal cord infarction and ischemic brain damage due to prolonged restricted respiration.
Interactions
Oxycodone is metabolized by the enzymes CYP3A4 and CYP2D6. Therefore, drugs that inhibit or induce these enzymes can affect the clearance and half-life of oxycodone. Spontaneous genetic variations in these enzymes can also impact oxycodone clearance, leading to variability in its half-life and potency among individuals.
For example, ritonavir and lopinavir/ritonavir can significantly increase oxycodone plasma concentrations by inhibiting CYP3A4 and CYP2D6. On the other hand, rifampicin can lower oxycodone plasma concentrations by inducing CYP3A4. It is important to consult with a healthcare professional if any medication modifications are necessary.
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